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Progress in Medical World part 4

Preemptive analgesia Stimuli cause the operation of central sensitization of spinal nerves that can be studied in addition to cessation of early peripheral afferent pain. This central sensitization termed "neurotransmitter" and neuroeptida. The potential of slow synaptic nerve produced by Aδ and C fibers in neurons of the dorsal edge. The last part of this potential to produce long-term depolarization of pain perception. Activation has close links with the increased permeability of calcium and activation of guanosine triphosphate-binding proteins and protein kinases. The clinical relevance of these changes is that the pain neurofifiologis-methyl-D-aspartic acid - the receptor in long-term management of chronic pain. Preemptive analgesia is an important therapeutic approach that uses a combination of local anesthetic, blockade neurixal, and inhibition of mediators of central neuroplasticity to prevent eternal pain mechanisms.
Progress in the management of acute pain, particularly those associated with the use of epidural analgesia, has produced better results, such as more rapid pain relief and patient satisfaction, decreased sedation after surgery, early ambulation, the incidence of complications is lower respirator and recovery functions of the stomach faster. Increased blood flow to the lower extremity arteries to increase functionality and reduce the incidence of vein thrombosis. Activity of the sympathetic nervous system caused by stress and possible morbidity of cardiac mus reduced when epidural anesthesia and analgesia used in patients who have a high risk in the operation. The experts have also expanded anesthesia analgesia techniques to cope with chronic pain.

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